Chapter 26. Parathyroid Hormone-Related Protein

نویسنده

  • John J. Wysolmerski
چکیده

19. Brown EM, MacLeod RJ 2001 Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 81:239-297. 20. Chang W, Chen TH, Pratt S, Shoback D 2000 Amino acids in the second and third intracellular loops of the parathyroid Ca2+sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem 27519955-19963. 21. Pearce SH, Williamson C, Kifor 0, Bai M, Coulthard MG, Davies M, Lewis-Barned N, McCredie D, Powell H, Kendall-Taylor P, Brown EM, Thakker RV 1996 A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. N Engl J Med 335:1115-1122. 22. Pollak MR, Seidman CE, Brown EM 1996 Three inherited disorders of calcium sensing. Medicine (Baltimore) 75:115-123. 23. Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor 0, Warren HB, Brown EM, Seidman JG, Seidman C E 1995 A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 11:389-394. 24. Wettschureck N, Lee E, Libutti SK, Offermanns S, Robey PG, Spiegel AM 2007 Parathyroid-specific double knockout of Gq and GI 1 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor. Mol Endocrinol 21:274-280. 25. Egbuna 01, Brown E M 2008 Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations. Best Pract Res Clin Rheumatol 22:129-148. 26. Hu J, Spiegel A M 2007 Structure and function of the human calcium-sensing receptor: Insights from natural and engineered mutations and allosteric modulators. J Cell Mol Med 11:908-922. 27. Russell J, Sherwood LM 1987 The effects of 1,25-dihydroxyvitamin D3 and high calcium on transcription of the pre-proparathyroid hormone gene are direct. Trans Assoc Am Physicians 100:25&262. 28. Moallem E, Kilav R, Silver J, Naveh-Many T 1998 RNA-Protein binding and post-transcriptional regulation of parathyroid hormone gene expression by calcium and phosphate. J Biol Chem 2735253-5259. 29. Ritter CS, Pande S, Krits I , Slatopolsky E, Brown A J 2008 Destabilization of parathyroid hormone mRNA by extracellular Ca2+ and the calcimimetic R-568 in parathyroid cells: Role of cytosolic Ca and requirement for gene transcription. J Mol Endocrinol 40:13-21. 30. Cozzolino M, Brancaccio D, Gallieni M, Galassi A, Slatopolsky E, Dusso A 2005 Pathogenesis of parathyroid hyperplasia in renal failure. J Nephrol 18:S-8. 31. Steddon SJ, Cunningham J 2005 Calcimimetics and calcilyticsfooling the calcium receptor. Lancet 365223772239. 32. Nemeth EF, Delmar EG, Heaton WL, Miller MA, Lambert LD, Conklin RL, Gowen M, Gleason JG, Bhatnagar PK, Fox J 2001 Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of uarathvroid hormone. J Pharmacol Exp Ther 299:323-331. 33. Silver J. Russell J, Sherwood LM 1985 Regulation by vitamin D metabolites of messenger ribonucleic acid ?or preprdparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 82:4270-4273. 34. Okazaki T. Igarashi T, Kronenberg HM 1988 S'-flanking region of the parathyroid hormone gene mediates negative regulation by 1,25-(OH)2 vitamin D3. J Biol Chem 263:2203-2208. 35. Kim MS, Fujiki R, Murayama A, Kitagawa H, Yamaoka K, Yamamoto Y. Mihara M, Takeyama K, Kato S 2007 IAlpha,25(OH)2D3induced transrepression by vitamin D receptor through E-box-type elements i n the human parathyroid hormone gene promoter. Mol Endocrinol 21:334-342. 36. Naveh-Many T, Rahamimov R, Livni N, Silver J 1995 Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 96: 1786-1 793. 37. Fukumoto S 2008 Physiological regulation and disorders of phosphate metabolism-pivotal role of fibroblast growth factor 23. Intern Med 47:337-343. 38. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T 2006 Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-774. 39. Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A. Obuse C, Togashi K, Tominaga M, Kita N. Tomiyama K, Iijima J, Nabeshima Y, Fujioka M, Asato R, Tanaka S, Kojima K, Ito J, Nozaki K. Hashimoto N, Ito T, Nishio T, Uchiyama T, Fujimori T, Nabeshima Y 2007 alpha-Klotho as a regulator of calcium homeostasis. Science 316:1615-1618. 40. Brownstein CA, Adler F, Nelson-Williams C, Iijima J. Li P, Imura A, Nabeshima Y, Reyes-Mugica M, Carpenter TO, Lifton RP 2008 A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci LJSA 1053455-3460. 41. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J 2007 The parathyroid is ti target organ for FGF23 in rats. J Clin Invest 117:40034008. 42. John MR. Arai M, Rubin DA, Jonsson KB, Juppner H 2002 Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology 143:1047-1057. 43. Brown EM 1983 Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab 56572-581.

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تاریخ انتشار 2009